Background :
@EN Recently, increasing numbers of chemotherapeutic agents are being used to treat cancer patients. Mucocutaneous complications are commonly seen in association with the administration of these medications.
@ES Objective :
@EN We conducted a study in cancer chemotherapy patients to determine the suspected chemotherapeutic agents and frequency of various mucocutaneous side effects in these patients.
@ES Methods :
@EN The study involved 140 patients admitted from December 1993 to September 1994 for cancer chemotherapy at Korea University Guro Hospital.
@ES Results :
@EN The mucocutaneous side effects during chemotherapy were alopecia (55%), hyperpigmentation (32.9%), stomatitis (20%), phlebitis (12.9%), flushing (8.6%) in descending order Visual grade II, IV alopecia patients were most common, but as the
chemotherapy cycle increased so, the severer the alopecia. Although the onset of the alopecia were variable, many patients experienced alopcia within 17 to 24 days after the start of chemotherapy. Serpentine supravenous fluorouracil
hyperpigmentation
were common (17.9%). Diffuse and longitudinal or horizontal or horizontal band like nail pigmentation were observed, and pigmented macules were also observed spontaneously. Other clinical manifestations accompanied with chemotherapy were tinea
infection(16.4%), acne(7.1%), oral thrush (7%), white nail band (4.3%), prurius(2.9%) in descending order.
@ES Conclusion :
@EN So, physicians need to be aware of the widely divergent cutaneous reactions which may occur with the use of anticancer medications. (Kor J Dermatol 1995;33(3) : 474~481)
|